Resolute Castle

About Resolute Castle

Exercise Resolute Castle is a U.S. Army Europe and Africa led, multinational, joint exercise which marries U.S. Army Reserve and National Guard, as well as allied and partner nation engineering unit training opportunities with the completion of real world construction projects that enhance training capabilities in various areas of Europe's eastern member-states. Resolute Castle is designed to reinforce regional partnerships and promote interoperability with host nation forces by providing improvements to existing infrastructure.

Resolute Castle 24 utilizes U.S. Army, U.S. Navy, and NATO engineers to increase partner capacity and strengthen capabilities across NATO’s eastern member states through real-world engineer-related training and the expansion of infrastructure in support of defender-series exercises.

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Video by Tyra Breaux

WRAIR new capability cryogenic electron microscope (Cryo-EM)

Walter Reed Army Institute of Research

June 28, 2023 | 13:08

The WRAIR cryogenic electron microscope (Cryo-EM) is the newest capability in the Emerging Infectious Disease Branch and is unique within the Department of Defense. It will enable WRAIR and other DOD researchers, the ability to rapidly determine the high-resolution 3D structure of viruses, proteins, antibodies and drugs. Techniques that will be used on the Cryo-EM includes single particle analysis, cryogenic electron tomography and in the future also microcrystal electron diffraction.

Samples can be imaged without requiring extensive preparation steps and the automation system allows for 12 samples to be tested back-to-back. 2D images are captured by a direct electron detector as a video to account for the motion changes of atoms. The resolution of 1.2 Å results in an exact view of the atoms positions within the sample. The 2D X-ray images from the outside and inside of the samples get aligned to create a 3D image of the sample. Since the imaging and structuring can be done at the same time, the process to obtain a 3D structure is reduced from hours to days compared to months to years that it can take with traditional methods. Researchers will be able to start and complete projects in a much faster time frame. This will allow WRAIR to respond quickly to future epidemics and other emerging infectious disease threats. (U.S. Army footage by Tyra Breaux/released)